Read e-book online Analytical Profiles of Drug Substances, Excipients, and PDF

By Harry G. Brittain

ISBN-10: 0122608267

ISBN-13: 9780122608261

Even though the legit compendia outline a drug substance as to id, purity, power, and caliber, they generally don't supply different actual or chemical info, nor do they checklist equipment of synthesis or pathways of actual or organic degradation and metabolism. Such info is scattered through the medical literature and the records of pharmaceutical laboratories. Edited by means of the affiliate Director of Analytical learn and improvement for the yank organization of Pharmaceutical Scientists, Analytical Profiles of Drug ingredients and Excipients brings this knowledge jointly into one resource. The scope of the sequence has lately been improved to incorporate profiles of excipient fabrics.

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K. S. Pang, Drug Metab. Disp,, 23, 255 (1994). 49. A. Rougier, C . I. Maibach, J. Pharrn. , 76, 451 (1 987). 50. D. J. D. Marrow, Clin. Pharmacol. , 57, 441 (1995). 46 GUNAWAN INDRAYANTO ET AL. 51. J. J. McCarthy, J. Clin. Pharm. , 12, 107 (1 987). 52. A. M. H. , 8, 157 (1955). BRINZOLAMIDE Rex Hall', Grey Wavner', John Baker', Glenn Stafford2, Wayne Schneider2, Way-Yu Lin2, Jesse May3, Michael Curtis4,Craig Struble4, Bette McCue4, Dan Jasheway4, and David McGee' (1) Analytical Chemistry (2) Research SuppodPharmaceutics (3) Research/Discovery Synthesis (4)PharmacokineticslDrug Metabolism ( 5 ) Toxicology Research and Development Alcon Laboratories, Inc.

Benzoic acid must be keep away from heat, flame, ignition sources, and moisture [44]. In aqueous solution, sodium benzoate forms a 1:1 complex with xanthine derivatives such as theophylline and caffeine [47]. 6. Drup metabolism, Pharmacologv. and Pharmacokinetics Benzoic acid is metabolized in the liver by conjugation with glycine, and is rapidly excreted in the urine as hippuric acid in most of animal species. It can also be excreted as benzoilglucoronic acid when ingested in a large dose. Benzoic acid can be found in urine as a metabolite of benzaldehyde and numerous other compounds [4,48].

The acid was then eluted with a 1/1 mixture of EtOH/1 N HCl, while the amine was recovered by using a 1/1 mixture of EtOH /20 % NH,OH. After separation, each compound could be subjected to a quantitative analysis. The United States Pharmacopoeia 23 [ 111 and Indonesian Pharmacopoeia IV [9] describe the assay of benzoic acid and salicylic acid in ointments. 5 cm) are used to effect the separation. 5 mL diluted phosphoric acid (3 in 10) to the first column (A), then packs above this a mixture of 4 g siliceous earth and ferric chloride-urea reagent.

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Analytical Profiles of Drug Substances, Excipients, and Related Methodology by Harry G. Brittain


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